Lupron Depot Kit (Leuprolide) is a medication that has been designed to mimic the actions of gonadotropin releasing hormone (GnRH or LHRH), the hormone released from the hypothalamus gland in the brain. The hypothalamus uses GnRH to send messages to the pituitary gland in the brain, which then sends messages to the ovaries in women, and the testicles in men, telling these organs to produce the sex hormones estrogen (in women) and testosterone (in men). Normally, GnRH comes from the hypothalamus in pulses, leading to the production of estrogen or testosterone. If GnRH came from the hypothalamus all of the time (rather than in "pulses"), it would have the opposite effect and "turn off" hormone production. This is what Lupron Depot Kit (Leuprolide) does.

When given to boys or men, Lupron Depot Kit (Leuprolide) reduces the amount of testosterone produced in the body. Lupron Depot Kit (Leuprolide) is used to treat Prostate Cancer because prostate cancer cells need testosterone in order to grow and reproduce.

When given to girls or women, Lupron Depot Kit (Leuprolide) reduces the amount of estrogen the body produces. It is used to treat Endometriosis because reduced levels of estrogen help to relieve the symptoms of this condition. It may also be used with iron supplementation to improve Anemia before surgery to remove uterine fibroids.

Lupron Depot Kit (Leuprolide) is also used to help slow down the development of the genital areas in boys (under the age of 9) and girls (under the age of 8) who are experiencing early puberty. As soon as the child stops using the medication, normal development is allowed to continue.

Lupron Depot Kit (Leuprolide) may be available under multiple brand names and/or in several different forms. Any specific brand name of Lupron Depot Kit (Leuprolide) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Lupron Depot Kit (Leuprolide) may not be used for all of the conditions discussed here.

Your doctor may have suggested Lupron Depot Kit (Leuprolide) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Lupron Depot Kit (Leuprolide), speak to your doctor. Do not stop using Lupron Depot Kit (Leuprolide) without consulting your doctor.

Do not give Lupron Depot Kit (Leuprolide) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Lupron Depot Kit (Leuprolide) if their doctor has not prescribed it.

The recommended dose of Lupron Depot Kit (Leuprolide) depends on the condition being treated and the frequency of injection that is most convenient for your condition.

Lupron Depot Kit (Leuprolide) is available as a daily injection (under the skin) or as a long-acting injection (into the muscle every 1, 3, or 4 months).

If you are giving yourself or your child daily injections, it is very important to follow the directions as printed on the package insert.

Be sure to check the solution for discolouration and particle matter before each use. Presterilized disposable syringes are supplied and the usual sites of injection are indicated in the package insert. To avoid damage to your skin and tissues, it is important to change the injection site on your body from time to time as recommended by your doctor.

The long-acting form of Lupron Depot Kit (Leuprolide) (depot) is injected into your muscle by your doctor at the appropriate intervals. It is very important to receive Lupron Depot Kit (Leuprolide) at the correct times. If you miss your appointment for an injection, make a new one as soon as possible.

It is important that Lupron Depot Kit (Leuprolide) be administered exactly as prescribed by your doctor. If you are using the daily injections and miss a dose, administer it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Many things can affect the dose and schedule of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose or schedule different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

Check the packaging instructions to find out whether to store Lupron Depot Kit (Leuprolide) in the refrigerator or at room temperature, as different brands have different requirements. Once mixed, the suspension should be used immediately or discarded. Protect from freezing and keep out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Lupron Depot Kit (Leuprolide). If you are concerned about side effects, discuss the risks and benefits of Lupron Depot Kit (Leuprolide) with your doctor.

The following side effects have been reported by at least 1% of people taking Lupron Depot Kit (Leuprolide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Acne
• breast tenderness
• headache
• hot flashes
• increased sweating (adult women)
• light, irregular vaginal bleeding
• menstrual cramps
• migraine
• nausea
• sleeping problems
• stopping of menstrual periods (adult women)
• vomiting
• weakness
• weight changes

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• burning, itching, redness, or swelling at site of injection
• decreased testicle size (adult men)
• difficulty urinating
• Erectile Dysfunction or decreased libido (adults)
• itchy skin rash
• mood swings (children; crying, irritability, restlessness, aggressive behaviour)
• muscle or joint pain
• nervousness
• numbness or swelling of the arms or legs
• severe bone pain
• signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
• swelling of feet or legs, fluid retention
• symptoms of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• vaginal burning, dryness, itching, or discharge
• vision changes
• symptoms of lung inflammation (e.g., shortness of breath, Dry Cough with exertion)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• pituitary apoplexy (e.g., sudden headache, vomiting, changes to vision, eye muscle movement problems, confusion or loss of consciousness or sudden, severe decrease in blood pressure and collapse)
• seizures
• severe chest or abdominal pain
• severe muscle or joint pain
• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Lupron Depot Kit (Leuprolide).

3.75 mg syringe
Each prefilled dual-chamber syringe contains sterile lyophilized microspheres composed of Lupron Depot Kit (Leuprolide) acetate incorporated in a biodegradable copolymer of lactic and glycolic acids. The front chamber contains 3.75 mg of Lupron Depot Kit (Leuprolide) acetate. Nonmedicinal ingredients: DL-lactic and glycolic acids copolymer, D-mannitol, and purified gelatin. The rear chamber of diluent contains carboxymethylcellulose sodium, D-mannitol, glacial acetic acid, USP to control pH, polysorbate 80, and water for injection USP. When mixed with diluent, the sterile lyophilized microspheres become a suspension, which is intended as an IM injection to be given once every month.

7.5 mg syringe
Each prefilled dual-chamber syringe contains sterile lyophilised microspheres composed of Lupron Depot Kit (Leuprolide) acetate incorporated in a biodegradable copolymer of lactic and glycolic acids. The front chamber contains 7.5 mg of Lupron Depot Kit (Leuprolide) acetate. Nonmedicinal ingredients: DL-lactic and glycolic acids copolymer, D-mannitol, and purified gelatin. The rear chamber of diluent contains carboxymethylcellulose sodium, D-mannitol, glacial acetic acid USP to control pH, polysorbate 80, and water for injection USP.

11.25 mg syringe
Each prefilled dual-chamber syringe contains sterile lyophilized microspheres composed of Lupron Depot Kit (Leuprolide) acetate incorporated in a biodegradable polymer of polylactic acid. The front chamber contains 11.25 mg of Lupron Depot Kit (Leuprolide) acetate. Nonmedicinal ingredients: D-mannitol and polylactic acid. The rear chamber of diluent contains carboxymethylcellulose sodium, D-mannitol, glacial acetic acid, USP to control pH, polysorbate 80, and water for injection USP. When mixed with diluent, the sterile lyophilized microspheres become a suspension, which is intended as an I.M. injection to be given once every 3 months.

22.5 mg syringe
Each prefilled dual-chamber syringe contains sterile lyophilized microspheres composed of Lupron Depot Kit (Leuprolide) acetate incorporated in a biodegradable polymer of polylactic acid. The front chamber contains 22.5 mg of Lupron Depot Kit (Leuprolide) acetate. Nonmedicinal ingredients: D-mannitol and polylactic acid. The rear chamber of diluent contains carboxymethylcellulose sodium, D-mannitol, glacial acetic acid, USP to control pH, polysorbate 80, and water for injection USP.

30 mg syringe
Each prefilled dual-chamber syringe contains sterile lyophilized microspheres composed of Lupron Depot Kit (Leuprolide) acetate incorporated in a biodegradable polymer of polylactic acid. The front chamber contains 30 mg of Lupron Depot Kit (Leuprolide) acetate. Nonmedicinal ingredients: D-mannitol and polylactic acid. The rear chamber of diluent contains carboxymethylcellulose sodium, D-mannitol, glacial acetic acid, USP to control pH, polysorbate 80, and water for injection USP.