Home > Drug >

Leukeran

Leukeran

(chlorambucil)

Leukeran (Chlorambucil) belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics called alkylating agents. It prevents the growth of cancer cells by interfering with the genetic material DNA, which is necessary for reproduction of cells.

Available form

Dosage

Tablet

2MG

Buy Leukeran Full drug details

What is Pocketpills?

As Canada's leading online pharmacy, we make sure you always have your meds on time. Use our app and website to fill prescriptions, order refills, and consult with our pharmacists. Take control of your health from home or on the go!

Easy refills, renewals, and reminders
Quick answers to your questions
Free delivery with SMS updates

Join us

We'd love to tell you more

We won't bore you with the details, but Health Canada requires you to sign in.

By proceeding you agree to our Terms of Use & Privacy Policy

Leukeran information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Leukeran (Chlorambucil) depends on the condition being treated.

For chronic lymphocytic leukemia, the usual adult starting dose is 0.15 mg per kilogram body weight per day until the total white blood cell count reaches the desired range. 4 weeks after the first course of treatment, the medication may be restarted at a dose of 0.1 mg per kilogram body weight per day.

For Hodgkin's disease, the usual dose is 0.2 mg per kilogram body weight per day for 4 to 8 weeks.

For Non-Hodgkin's Lymphoma, the usual dose is 0.1 mg to 0.2 mg per kilogram body weight per day for 4 to 8 weeks initially. Maintenance treatment is then started at a reduced daily dose or with intermittent courses of treatment. Leukeran (Chlorambucil) may be included as part of a combination treatment with other antineoplastic medications.

For Waldenstrom's macroglobulinemia, usual dose is 0.1 mg to 0.2 mg per kilogram body weight per day initially. Maintenance treatment is then given at a reduced daily dose of 0.03 mg to 0.1 mg per kilogram body weight per day.

As well as interfering with the genetic material DNA of cancer cells, Leukeran (Chlorambucil) can interfere with some of your normal cells. This can cause a number of side effects. Keep track of any side effects and report them to your doctor as suggested in the section, "What side effects are possible with Leukeran (Chlorambucil)?"

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Leukeran (Chlorambucil) exactly as prescribed by your doctor. Do not stop taking Leukeran (Chlorambucil) without talking with your doctor. If you vomit shortly after taking a dose of the medication, call your doctor for instructions on whether to skip that dose or to take another dose. If you miss a dose, ask your doctor for instructions. Do not take a double dose to make up for a missed one.

Store Leukeran (Chlorambucil) in a refrigerator, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Leukeran (Chlorambucil). If you are concerned about side effects, discuss the risks and benefits of Leukeran (Chlorambucil) with your doctor.

The following side effects have been reported by at least 1% of people taking Leukeran (Chlorambucil). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

changes in menstrual period
Diarrhea
nausea and vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

mouth ulcers
muscle twitching or jerking movements
muscle weakness or numbness
numbness or tingling in fingers and toes
persistent cough with shortness of breath
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of bladder inflammation (e.g., pain or burning with urination, frequent or urgent need to urinate)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
skin rash
symptoms of an infection such as Fever, chills, or painful and difficult urination
tremors

Stop taking the medication and seek immediate medical attention if any of the following occur:

blisters on skin
seizures
severe skin rash or skin blisters
symptoms of a serious allergic reaction such as Hives; difficulty breathing; or swelling of the eyelids, throat, and mouth

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Leukeran (Chlorambucil).

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Leukeran (Chlorambucil).

Blood clotting: Leukeran (Chlorambucil) can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor of any signs that your blood is not clotting as quickly. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.

Infection: As well as killing cancer cells, Leukeran (Chlorambucil) can reduce the number of cells that fight infection in the body (white blood cells). Avoid contact with people who have contagious infections and tell your doctor if you begin to notice signs of an infection such as fever or chills.

Kidney problems: If you have kidney problems, discuss with your doctor how Leukeran (Chlorambucil) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Leukeran (Chlorambucil), and whether any special monitoring is needed.

Liver problems: If you have severe liver problems, discuss with your doctor how Leukeran (Chlorambucil) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Leukeran (Chlorambucil), and whether any special monitoring is needed.

Secondary cancer: When used for long periods of time, Leukeran (Chlorambucil) can increase the risk of developing leukemia. If you are concerned about this, talk to your doctor about the risks and benefits of using Leukeran (Chlorambucil).

Seizures: Leukeran (Chlorambucil) may increase the risk of seizures in people with a history of seizures, with nephrotic syndrome, or with a head injury. Talk to your doctor about whether any special monitoring is needed.

Surgery: If you need surgery, tell your doctor or anesthetist that you are taking Leukeran (Chlorambucil).

Pregnancy: There is a possibility of birth defects if either the man or woman is taking Leukeran (Chlorambucil) at the time of conception, or if it is taken during pregnancy. Infertility may occur with the use of Leukeran (Chlorambucil). Use effective birth control while taking Leukeran (Chlorambucil). If you become pregnant while taking Leukeran (Chlorambucil), contact your doctor immediately.

Breast-feeding: Leukeran (Chlorambucil) may pass into breast milk. Women taking Leukeran (Chlorambucil) should not breast-feed.

Children: The safety and effectiveness of using Leukeran (Chlorambucil) have not been established for children.

Continue with Pocketpills

All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

Helpful links

See these other medications
that relate to

FAQs

Do I need a valid prescription (Rx) to order prescription medication?

Yes, you need a valid prescription, or Rx for short, from a Canadian prescriber to purchase medication that requires a prescription. If you need a new prescription, please contact us and we can help connect you with a doctor or we will reach out to your doctor for a renewal.

How can I refill my medication?

We will gladly coordinate with your doctor and insurance company to make sure you never run out of the medication you need. Additionally, we will remind you when it's time to schedule a delivery for your refill. You can also opt into automatic refills online, in the app, or by calling us at 1-855-950-7225.

Is Pocketpills free? How much does it cost?

Yes, Pocketpills services are free! You only pay your portion of your copay, and there are no hidden delivery or service fees. We'll transfer your prescriptions from your old pharmacy, find savings, and hand-deliver your medications at no extra cost.

What insurance plans do you accept?

We accept all insurance plans and direct bill ODB, OHIP+, and PharmaCare.

How much is shipping cost For Leukeran in Canada?

Shipping cost for Leukeran to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Leukeran delivered to my home?

You could get Leukeran delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.