Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Halaven (Eribulin).
Abnormal heart rhythms: Halaven (Eribulin) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Halaven (Eribulin). You are more at risk for this type of abnormal heart rhythm and its complications if you:
- are female
- are older than 65 years of age
- have a family history of sudden cardiac death
- have a history of heart disease or abnormal heart rhythms
- have a slow heart rate
- have congenital prolongation of the QT interval
- have Diabetes
- have had a Stroke
- have low potassium, magnesium, or calcium levels
- have nutritional deficiencies
If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Halaven (Eribulin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Halaven (Eribulin), and whether any special monitoring is needed.
Anemia: Halaven (Eribulin) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.
Infection: As well as killing cancer cells, Halaven (Eribulin) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.
Kidney function: Kidney Disease or reduced kidney function may cause Halaven (Eribulin) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Halaven (Eribulin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Halaven (Eribulin), and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause Halaven (Eribulin) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Halaven (Eribulin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Halaven (Eribulin), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Halaven (Eribulin).
Pregnancy: Halaven (Eribulin) may harm a developing fetus if it is used by the mother while pregnant. Halaven (Eribulin) should not be used during pregnancy. If you become pregnant while taking Halaven (Eribulin), contact your doctor immediately.
Breast-feeding: It is not known if Halaven (Eribulin) passes into breast milk. If you are a breast-feeding mother and are taking Halaven (Eribulin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Halaven (Eribulin) have not been established for children.