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Doxepin

Doxepin

Doxepin belongs to the family of medications known as tricyclic antidepressants. It is used to treat Depression, especially when anxiety is one of the symptoms.

Available form

Capsule

Dosage

150mg

Manufacturers

Aa Pharma

Branded drugs

Sinequan

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Doxepin information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Directions of use

The recommended adult daily dose of doxepin ranges from 75 mg to 300 mg in 3 divided doses. The usual starting dose is 25 mg 3 times daily. The total dose can be taken at bedtime once the final dose is reached (as long as the final dose is 150 mg per day or less). Lower doses may be needed for seniors.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Doxepin at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Doxepin. If you are concerned about side effects, discuss the risks and benefits of Doxepin with your doctor.

The following side effects have been reported by at least 1% of people taking Doxepin. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Constipation
dizziness
drowsiness
Dry Mouth
flushing
headache
increased or decreased appetite
Low Blood Pressure
nausea
tiredness or weakness (mild)
unpleasant taste
vision problems (e.g., blurred vision)
weight gain

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

agitation
anxiety
confusion
decreased or increased sexual ability
decreased or increased sweating
difficulty speaking
disorientation
eye pain
fast or irregular heartbeat
hallucinations
increased sensitivity to sunlight
irritability

loss of balance control
mask-like face
nervousness or restlessness
nightmares
numbing or tingling of the fingers or toes
problems urinating
ringing or buzzing in the ears
shuffling walk
skin rash or itching
tremors or shakiness
trouble sleeping
vomiting

Stop taking the medication and seek immediate medical attention if any of the following occur:

seizures
symptoms of a Anaphylaxis (severe allergic reaction) (e.g., swelling of face and tongue, difficulty breathing, Hives)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Doxepin.

10 mg
Each pink and scarlet hard gelatin capsule, imprinted "APO 10", contains doxepin HCl equivalent to doxepin base 10 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid, and talc; capsule shell: D&C Red No. 28, D&C Red No. 33, D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 40, gelatin, and titanium dioxide; edible black ink: pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and D&C Yellow No. 10 Aluminum Lake; may contain: n-butyl alcohol, propylene glycol, and SDA-3A alcohol.

25 mg
Each pink and blue hard gelatin capsule, imprinted "APO 25", contains doxepin HCl equivalent to doxepin base 25 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid, and talc; capsule shell: D&C Red No. 28, FD&C Blue No.1, FD&C Red No. 40, titanium dioxide, and gelatin; edible black ink: pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and D&C Yellow No. 10 Aluminum Lake; may contain: n-butyl alcohol, propylene glycol, and SDA-3A alcohol.

50 mg
Each flesh and pink hard gelatin capsule, imprinted "APO 50", contains doxepin HCl equivalent to doxepin base 50 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid, and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, FD&C Blue No. 1, FD&C Red No. 40, titanium dioxide, and gelatin; edible black ink: pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and D&C Yellow No. 10 Aluminum Lake; may contain: n-butyl alcohol, propylene glycol, and SDA-3A alcohol.

75 mg
Each flesh and flesh hard gelatin capsule, imprinted "APO 75", contains doxepin HCl equivalent to doxepin base 75 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid, and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, FD&C Blue No. 1, titanium dioxide, and gelatin, edible black ink: pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and D&C Yellow No. 10 Aluminum Lake; may contain: n-butyl alcohol, propylene glycol, and SDA-3A alcohol.

100 mg
Each flesh and blue hard gelatin capsule, imprinted "APO 100", contains doxepin HCl equivalent to doxepin base 100 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic, acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, FD&C Blue No. 1, titanium dioxide, and gelatin, edible black ink: pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and D&C Yellow No. 10 Aluminum Lake; may contain: n-butyl alcohol, propylene glycol, and SDA-3A alcohol.

There may be an interaction between doxepin and any of the following:

acetylsalicylic acid (Asa)
alcohol
Alfuzosin
altretamine
anticholinergic medications (e.g., atropine)
barbiturates (e.g., Phenobarbital)
benzodiazepines (e.g., Diazepam, Lorazepam)
beta-2 agonists (e.g., salmeterol, formoterol, fenoterol, terbutaline)
bupriopion
Carbamazepine
chloroquine
cholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
Cimetidine
Cinacalcet
ciprofloxacin
Clonidine
Decongestant Nasal sprays (e.g., oxymetazoline, phenylephrine, naphazoline)
delavirdine
Desmopressin
Divalproex
Dronedarone
Duloxetine
guanethidine
lithium
MAO inhibitors (e.g., phenelzine, Moclobemide)

methyldopa
Methylphenidate
Metoclopramide
Nilotinib
nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., Celecoxib, Diclofenac, Ibuprofen, Naproxen)
other medications that can cause sedation (e.g., sedatives, sleeping pills, anaesthetics)
Paroxetine
Pimozide
propoxyphene
protease inhibitors for HIV (e.g., ritonavir, lopinavir, tipranavir)
quinidine
quinine
rifabutin
rifampin
SSRI antidepressants (e.g., Fluoxetine, Fluvoxamine)
stimulant medications (e.g., appetite suppressants, amphetamines, Epinephrine, norepinephrine)
terbinafine
Tetrabenazine
thioridazine
Tramadol
Valproic acid
Warfarin
Yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Doxepin. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Doxepin.

Drowsiness/reduced alertness: Since doxepin may cause drowsiness, avoid driving or engaging in activities requiring mental alertness and physical coordination until you determine that the medication does not affect you in this way.

Heart diseases: Tricyclic antidepressant medications such as doxepin, particularly when taken in high doses, can cause abnormal heart rhythms. People with a history of heart disease and seniors should discuss with their doctor how Doxepin may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Doxepin, and whether any special monitoring is needed.

Mania or hypomania: Doxepin may cause activation of mania or hypomania. People with a history of bipolar disorder should be closely monitored by their doctor while using Doxepin.

Medical conditions: People with reduced liver function or seizures should discuss with their doctor how Doxepin may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Doxepin, and whether any special monitoring is needed.

Suicidal or agitated behaviour: People taking antidepressants such as doxepin may feel agitated (restless, anxious, aggressive, emotional, trouble sleeping, and feeling not like themselves), or they may want to hurt themselves or others. If you notice any changes in mood, behaviours, thoughts, or feelings in yourself or someone who is taking Doxepin, contact a doctor immediately. Your doctor will monitor you closely for behaviour changes, especially at the start of treatment or when your dose is increased or decreased.

Surgery: Using doxepin before, during, and after surgery may increase the risk of developing abnormal heart rhythms. The risks and benefits of continuing doxepin during elective surgery should be discussed with your doctor. Your doctor may recommend to stop or reduce the dose of doxepin several days prior to the scheduled surgery.

Thyroid disease: Patients who have an overactive thyroid (Hyperthyroidism) or are taking thyroid medication should be monitored closely by their doctor while taking doxepin.

Withdrawal: Stopping Doxepin abruptly after taking it for a long time may produce nausea, headache, and malaise. Experiencing these symptoms does not mean you are addicted. Do not suddenly stop taking Doxepin if you have been taking it for a while. If you are to stop taking Doxepin, contact your doctor, who will advise you on how to gradually stop taking Doxepin.

Pregnancy: Doxepin should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Doxepin, contact your doctor immediately.

Breast-feeding: It is not known if doxepin passes into breast milk. If you are a breast-feeding mother and are taking Doxepin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Doxepin have not been established for children.

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All material © 1996-2025 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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