Available in:Tablet
Dosage:25MG, 50MG, 100MG
Manufacturer:Merck
Available in:Tablet
Dosage:15MG, 30MG, 45MG
Manufacturer:Takeda
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The usual dose of Januvia (Sitagliptin) is 100 mg taken by mouth once daily with or without food.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Januvia (Sitagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Januvia (Sitagliptin) at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
The usual starting dose for adults is 15 mg or 30 mg taken once daily. Diet and exercise programs should be continued while taking Actos (Pioglitazone). Your doctor may decide to increase the dose of Actos (Pioglitazone) to 45 mg daily if lower doses do not sufficiently reduce your blood sugar levels. The use and dose of Actos (Pioglitazone) for children must be determined by their doctor.
Actos (Pioglitazone) may be taken with or without food, and should be taken daily and at regular intervals as prescribed by the doctor so that blood levels of the medication always remain in an effective range.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without talking to your doctor.
It is important to take Actos (Pioglitazone) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Actos (Pioglitazone) at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Januvia (Sitagliptin). If you are concerned about side effects, discuss the risks and benefits of Januvia (Sitagliptin) with your doctor.
The following side effects have been reported by at least 1% of people taking Januvia (Sitagliptin). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Januvia (Sitagliptin).
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Actos (Pioglitazone). If you are concerned about side effects, discuss the risks and benefits of Actos (Pioglitazone) with your doctor.
The following side effects have been reported by at least 1% of people taking Actos (Pioglitazone). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Actos (Pioglitazone).
You should be aware of the signs of low blood sugar and what to do about it when taking any medication that reduces your blood sugar, including Actos (Pioglitazone). Signs of low blood sugar include:
If you experience symptoms of low blood sugar, eat glucose tablets or gel, corn syrup, honey, or sugar cubes, or drink juice or a non-diet soft drink, as discussed with your doctor or diabetes educator.
25 mg
Each pink, round, film-coated tablet, with "221" on one side, contains 25 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
50 mg
Each light beige, round, film-coated tablet, with "112" on one side, contains 50 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
100 mg
Each beige, round, film-coated tablet, with "277" on one side, contains 100 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
15 mg
Each white to off-white, round, convex, non-scored tablet, with "ACTOS" printed on one side and "15" on the other, contains Actos (Pioglitazone) HCl equivalent to 15 mg of Actos (Pioglitazone). Nonmedicinal ingredients: carboxymethylcellulose calcium, hydroxypropyl cellulose, lactose monohydrate, and magnesium stearate.
30 mg
Each white to off-white, round, flat, non-scored tablet, with "ACTOS" printed on one side and "30" on the other, contains Actos (Pioglitazone) HCl equivalent to 30 mg of Actos (Pioglitazone). Nonmedicinal ingredients: carboxymethylcellulose calcium, hydroxypropyl cellulose, lactose monohydrate, and magnesium stearate.
45 mg
Each white to off-white, round, flat, non-scored tablet, with "ACTOS" printed on one side and "45" on the other, contains Actos (Pioglitazone) HCl equivalent to 45 mg of Actos (Pioglitazone). Nonmedicinal ingredients: carboxymethylcellulose calcium, hydroxypropyl cellulose, lactose monohydrate, and magnesium stearate.
Januvia (Sitagliptin) should not be taken by anyone who is allergic to Januvia (Sitagliptin) or to any of the ingredients of the medication.
Do not take Actos (Pioglitazone) if you:
There may be an interaction between Januvia (Sitagliptin) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Januvia (Sitagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
There may be an interaction between Actos (Pioglitazone) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Actos (Pioglitazone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Januvia (Sitagliptin).
Hypersensitivity reaction: A Anaphylaxis (severe allergic reaction) called hypersensitivity reaction has occurred for some people with the use of Januvia (Sitagliptin). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including Fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Immune system: Januvia (Sitagliptin) can reduce the number of cells that fight infection in the body (white blood cells). This side effect may be more of a concern for people who already have a weakened immune system. People who have HIV infection, have had an organ transplant and are taking medications to reduce the activity of the immune system, or are taking medication to treat certain types of cancer are more likely to have a weakened immune system. If any of these conditions apply to you, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Kidney function: Januvia (Sitagliptin) has been reported to cause decreased kidney function and may cause kidney failure. Your doctor may recommend regular testing to check your kidney function while you are taking Januvia (Sitagliptin). If you notice signs of kidney problems, such as decreased urine production; swelling in your hands, wrists, feet, or ankles; difficulty breathing, or weakness, contact your doctor as soon as possible.
People with decreased kidney function may require lower doses of Januvia (Sitagliptin). If you have Kidney Disease or decreased kidney function, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Januvia (Sitagliptin) is not recommended for people with moderately to severely reduced kidney function.
Liver function: Januvia (Sitagliptin) is not recommended for people with severely reduced liver function. People with moderately reduced liver function should discuss with their doctor how Januvia (Sitagliptin) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Low blood glucose (sugar): Hypoglycemia (low blood sugar) can occur when Januvia (Sitagliptin) is used in combination with metformin and a sulfonylurea (e.g., glyburide, gliclazide), or insulin. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking Januvia (Sitagliptin), contact your doctor.
Pancreatitis: Januvia (Sitagliptin) may cause pancreatitis (inflammation of the pancreas). People with a history of pancreatitis, gallstones, Alcoholism, or high triglycerides may be more at risk of experiencing this. If you experience prolonged and severe abdominal pain with or without vomiting while taking Januvia (Sitagliptin), contact your doctor immediately.
Type 1 Diabetes and diabetic ketoacidosis: Januvia (Sitagliptin) should not be used by people with type 1 diabetes or to treat diabetic ketoacidosis (increased ketones in the blood or urine).
Pregnancy: Januvia (Sitagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Januvia (Sitagliptin), contact your doctor immediately.
Breast-feeding: It is not known if Januvia (Sitagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Januvia (Sitagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Januvia (Sitagliptin) have not been established for children.
Seniors: Seniors are more likely to have decreased renal function and may require lower doses of Januvia (Sitagliptin).
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Actos (Pioglitazone).
Bladder: Taking Actos (Pioglitazone) may increase the risk of developing bladder cancer. If you have risk factors for bladder cancer, such as age, smoking, or someone in your family has had bladder cancer you may be more likely to develop this disease. Do not use Actos (Pioglitazone) if you have or have had bladder cancer.
If you experience symptoms such as blood or red colour in your urine, an urgent need to urinate, pain while urinating, or pain in the back or lower abdomen, talk to your doctor right away.
Fractures: Actos (Pioglitazone) has been associated with an increased incidence of bone fracture for female patients. You and your doctor should consider the risk of fractures. Talk to your doctor if you have any concerns.
Heart failure: Actos (Pioglitazone) can cause fluid buildup in the body, which may lead to Congestive Heart Failure. Actos (Pioglitazone) should not be used by anyone who has any degree of heart failure, or anyone who is at risk of heart failure (including people with swelling due to fluid buildup). If you develop fluid buildup or swelling, shortness of breath, fatigue, or excessive weight gain while taking Actos (Pioglitazone), you should consult your doctor immediately.
Liver: Although liver problems have not been observed with Actos (Pioglitazone), another similar medication has caused liver problems in a small number of people. You should report any signs of liver problems (abdominal or stomach pain, dark urine, loss of appetite, nausea or vomiting, unusual tiredness or weakness, or yellow eyes or skin) to your doctor at once.
Use with other diabetes medications: Actos (Pioglitazone) should not be used with insulin. It should not be used in combination (i.e., triple therapy) with both metformin and a sulfonylurea (e.g., glyburide, glicazide); however, it may be used with either metformin or a sulfonylurea.
Vision: Actos (Pioglitazone) may cause fluid to build up in the eye (macular edema) causing vision changes. If you experience any change to your vision, contact your doctor.
Pregnancy: Actos (Pioglitazone) has not been studied for use by pregnant women. Actos (Pioglitazone) should not be used during pregnancy. In general, blood sugar should be controlled during pregnancy by using insulin injections. If you become pregnant while taking Actos (Pioglitazone), contact your doctor immediately.
Breast-feeding: It is not known if Actos (Pioglitazone) passes into breast milk. If you are a breast-feeding mother and are taking Actos (Pioglitazone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Actos (Pioglitazone) have not been established for children.
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