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Cisplatin

Cisplatin

(cisplatin)

Cisplatin belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics known as platinum-containing compounds. Cisplatin stops the growth of cancer cells by interfering with the genetic material DNA, which is necessary for cells to multiply.

Available form

Dosage

Injectable

1MG/ML

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Cisplatin information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose and dosing schedule of cisplatin varies according to the specific type of cancer being treated, the response to therapy, and the other medications or treatments being used. The dose given is based on body size.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor. Your doctor may decide on a dosage schedule different from that described here.

Cisplatin is available as an intravenous (into the vein) injection. It is usually injected through a specially prepared site on the skin. Cisplatin is most often given as a single injection every 3 to 4 weeks or as one injection (of a smaller dose) daily for 5 days every 3 to 4 weeks.

Very careful handling of Cisplatin is required. Cisplatin should only be given by health care professionals familiar with the use of cancer chemotherapy. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

Note that it is very important to drink plenty of fluids right after your treatment. Your doctor may want you to drink extra fluids while taking Cisplatin in order to help you pass more fluid and protect your kidneys. You should try to drink a glass of water every 1 to 2 hours and empty your bladder regularly for at least 24 hours after your treatment.

It is important to use Cisplatin exactly as recommended by your doctor. If you miss an appointment to receive cisplatin, contact your doctor as soon as possible to reschedule your appointment.

As well as interfering with the genetic material DNA of cancer cells, cisplatin can interfere with some of your body’s normal cells. This can cause a number of side effects. Keep track of any side effects and report them to your doctor as suggested in the section, "What side effects are possible with Cisplatin?"

Cisplatin is stored at room temperature. It should be protected from light and kept out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who uses Cisplatin. If you are concerned about side effects, discuss the risks and benefits of Cisplatin with your doctor.

The following side effects have been reported by at least 1% of people using Cisplatin. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

loss of appetite
nausea and vomiting
taste disturbances
temporary hair loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision
Diarrhea
difficulty in ability to distinguish colours
difficulty walking
hearing difficulties
loss of balance
loss of reflexes
muscle cramps
numbness or tingling in fingers or toes
ringing in ears
severe nausea and vomiting
unusual tiredness or weakness
walking problems

Stop taking the medication and seek immediate medical attention if any of the following occur:

pain, redness, or swelling at site of injection
seizures
signs of a serious allergic reaction (difficulty breathing, wheezing, swelling of the face and throat, increased heart rate, dizziness)
signs of bleeding (e.g., unusual bruising or bleeding, pinpoint red spots on skin, black tarry stools, bloody nose, blood in urine, coughing blood, cuts that don't stop bleeding)
signs of infection (symptoms may include Fever or chills, sore throat, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, painful or difficult urination, or listlessness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using Cisplatin.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Cisplatin.

Blood clotting: Cisplatin can reduce the number of platelet cells in the blood and increase your risk of bleeding. Tell your doctor immediately if you notice any signs that your blood is not clotting as quickly as usual (e.g., black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding). Your doctor will do blood tests regularly to monitor the number of platelets in your blood.

Gout: Cisplatin may cause high levels of uric acid in the blood, making gout more likely to occur. If you have gout or a history of gout, discuss with your doctor how Cisplatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Cisplatin, and whether any special monitoring is needed. Report any unusual joint pain or swelling to your doctor as soon as possible.

Hearing impairment: Cisplatin can cause permanent hearing damage and should not be given to anyone with hearing impairment. Your hearing will be monitored closely while you are using Cisplatin.

Infection: In addition to killing cancer cells, Cisplatin can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Cisplatin can reduce kidney function and cause kidney damage. For this reason, it is very important to drink plenty of fluids right after your treatment. Your doctor may want you to drink extra fluids while taking Cisplatin in order to help you pass more fluid and protect your kidneys. Your doctor will monitor your kidney function closely while you are using Cisplatin. If you have reduced kidney function you should not use Cisplatin.

Nervous system: Cisplatin can cause damage to the nervous system. If you experience symptoms such as loss of taste, tingling in the hands or feet, or balance trouble, tell your doctor as soon as possible. These side effects are often reversible if the medication is stopped early.

Pregnancy: There is a possibility of birth defects if either the man or woman is using cisplatin at the time of conception, or if it is taken during pregnancy. Cisplatin should not be used during pregnancy unless the benefits outweigh the risks.

Use effective birth control while you are being treated with Cisplatin. If you become pregnant while taking Cisplatin, contact your doctor immediately.

Breast-feeding: Cisplatin passes into breast milk. Women receiving Cisplatin should not breast-feed.

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