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Allopurinol

Allopurinol

Allopurinol is an inhibitor of xanthine oxidase, a substance in the body that is responsible for the product of uric acid. It is used to prevent Gout, Kidney Stones, and kidney damage caused by uric acid.

Available form

Tablet, Professional Service, Suspension

Dosage

100mg, 200mg, 300mg, compound

Manufacturers

Angita Pharma, Apotex, Jamp Pharma Corporation, Marcan Pharmaceuticals, Pro Doc Limitée

Branded drugs

Zyloprim

Buy Allopurinol Full drug details

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Allopurinol information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Directions of use

The recommended dose ranges from 100 mg to 800 mg daily in 1 to 3 divided doses, depending on the condition being treated. Take allopurinol after eating, to help minimize upset stomach.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Allopurinol exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store at room temperature in a dry place and keep out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Allopurinol. If you are concerned about side effects, discuss the risks and benefits of Allopurinol with your doctor.

The following side effects have been reported by at least 1% of people taking Allopurinol. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Diarrhea
dizziness
drowsiness
headache
indigestion
nausea or vomiting occurring without other side effects
stomach pain occurring without other side effects
hair loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

numbness, tingling, pain, or weakness in hands or feet
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour, rapid weight gain)
swelling of face, fingers, feet, or lower legs
vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

chills, Fever, muscle aches or pains, nausea, or vomiting (especially if this happens with or shortly after a skin rash)
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Allopurinol.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Allopurinol.

Drowsiness/reduced alertness: Allopurinol may cause drowsiness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by Allopurinol.

Use appropriate caution if you plan to do activities requiring alertness.

Gout: Do not start allopurinol treatment until an acute attack of gout has completely subsided, as further attacks may be caused by Allopurinol. Acute gout attacks may occur at the start of treatment with allopurinol for people who have not taken the medication before. If an acute gout attack develops after starting Allopurinol, call your doctor.

Hypersensitivity syndrome: A Anaphylaxis (severe allergic reaction) called hypersensitivity syndrome has occurred for some people with the use of allopurinol. This reaction involves a number of organs in the body and may be fatal if not treated quickly. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Kidney function: Kidney Disease or reduced kidney function may cause Allopurinol to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Allopurinol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Allopurinol, and whether any special monitoring is needed.

Liver function: Allopurinol may reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how Allopurinol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Allopurinol, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Allopurinol.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Skin rash: If you develop a skin rash, stop taking Allopurinol and contact your doctor. The skin rash may be the first sign of a serious allergic reaction to the medication.

Pregnancy: Allopurinol is not recommended for women who are or may become pregnant unless the potential benefits outweigh the possible risks. If you are or may be pregnant, talk to your doctor about the risks and benefits of Allopurinol.

Breast-feeding: Allopurinol passes into breast milk. If you are a breast-feeding mother and are taking allopurinol, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Children should not take allopurinol, except in cases where increased uric acid levels in the blood are associated with cancer or with Lesch-Nyhan syndrome. The safety and effectiveness of allopurinol for this age group have not been established in treatment of other conditions.

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