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Alprostadil

Alprostadil

(alprostadil)

Alprostadil, also known as prostaglandin E1, belongs to a class of medications known as vasodilators. It is used to treat babies with certain types of congenital heart defects.

Available form

Dosage

Injectable

500MCG/ML

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Alprostadil information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended initial dosage of alprostadil is calculated by your doctor based on body weight. When the desired effect on the ductus arteriosus (a passageway in your baby's heart) is achieved, the infusion rate is usually decreased to the lowest possible dose while still maintaining the desired effect on the ductus arteriosus.

Alprostadil is usually given through a continuous intravenous infusion into a vein by a health care professional in a hospital setting. It can also be given into an artery at the opening of the ductus arteriosus.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. Your doctor may have recommended a different dose from the one listed here.

Store Alprostadil in the refrigerator at 2°C to 8°C. Once the medication has been prepared by dilution, it must be used within 24 hours, after which it must be discarded. Protect from light and keep out of reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who uses Alprostadil. If you are concerned about side effects, discuss the risks and benefits of Alprostadil with your baby's doctor.

While your baby is receiving alprostadil, health care professionals in the hospital will be monitoring your baby for any possible side effects. The following side effects have been reported by at least 1% of people using Alprostadil. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if your baby experiences these side effects and they are severe or bothersome.

apnea (episodes of regular breathing with pauses)
Diarrhea
Fever
flushing
infections
Low Blood Pressure (symptoms include dizziness or fainting)
slow or fast heartbeat
spitting up
swelling of the arms, feet, or legs

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your baby's doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

abnormal heart rhythm
Blood Clots
blood in urine
bluish skin colour
convulsions or seizures
feeling drowsy or sluggish
hypothermia (abnormally low body temperature; e.g., shivering, shallow breathing, drowsiness, loss of consciousness)
irritability or jitteriness
low blood sugar levels (e.g., dizziness, lack of energy, sweating, or shakiness)
low potassium levels (e.g., weakness, muscle cramps, Constipation, nausea or vomiting, heart palpitations, increased thirst or urination, tingling or numbness)
stiffness

Stop the medication and seek immediate medical attention if any of the following occur:

bleeding
cardiac arrest
signs of a serious allergic reaction (e.g., shortness of breath or difficulty breathing; Hives; swelling of the eyes, mouth, lips, or throat)
troubled breathing or stopped breathing

Some people may experience side effects other than those listed. Check with your baby's doctor if you notice any symptom that worries you while your baby is on Alprostadil.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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