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Tagrisso

Tagrisso

(osimertinib)

Tagrisso (Osimertinib) belongs to a group of cancer-fighting medications called antineoplastics, and more specifically, to a group of medications called protein kinase inhibitors. It works by recognizing certain types of cancer cells and blocking the action of chemicals that cause them to divide and grow.

Available form

Dosage

Tablet

80MG

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Tagrisso information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Tagrisso (Osimertinib) for adults is 80 mg taken by mouth once a day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Tagrisso (Osimertinib) may be taken with food or on an empty stomach; however, it should be taken the same way, at approximately the same time, every day. Swallow Tagrisso (Osimertinib) whole with water. Do not crush, split, or chew the tablet.

If you are unable to swallow the tablet whole, it may be dropped into 50 mL of non-carbonated, room temperature water immediately before taking the dose. Stir the water and tablet until the tablet has dissolved and then immediately swallow the water containing the dissolved tablet. Rinse the cup with another 50 mL of water and drink the water that was used to rinse the cup. This will ensure that you get all the medication that was left in the cup.

It is important to take Tagrisso (Osimertinib) exactly as prescribed by your doctor. If you miss a dose, and it is less than 12 hours since the missed dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Tagrisso (Osimertinib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Tagrisso (Osimertinib). If you are concerned about side effects, discuss the risks and benefits of Tagrisso (Osimertinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Tagrisso (Osimertinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Constipation
cough
decreased appetite
Diarrhea
dizziness
dry, itchy skin
fatigue
hair loss
headache
mouth sores
nausea
nose bleeds
runny or stuffy nose
sinus or throat infections
trouble concentrating
vomiting
weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:

back pain
blistering, peeling, redness, tingling or swelling of palms of hands or bottoms of feet
bruise-like or raised marks on skin
eye pain and sensitivity to light
shortness of breath
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of an eye infection (e.g., itchy, swollen, red eyes with discharge)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don 't stop bleeding)
signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
skin and nail problems (itching, dry skin, rash, blisters around the nail, swelling, discolored, or detached nails)
swollen eye lids
symptoms of irregular heartbeat (e.g., chest pain; dizziness; rapid, pounding heartbeat; shortness of breath)
symptoms of lung inflammation (e.g., shortness of breath, cough, chest pain, painful breathing, wheezing, tiredness, coughing up blood)
vision problems

Stop taking the medication and seek immediate medical attention if any of the following occur:

breathing problems (e.g., sudden worsening or shortness of breath, bluish colour of skin, lips or fingernails, irregular heartbeat, sleepiness, loss of consciousness)
chest pain
signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worst when breathing in, coughing, coughing up blood, sweating, or passing out)
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a serious skin reaction (such as skin rash; red skin; blistering of the lips, eyes, or mouth; skin peeling; fever; or joint pain)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tagrisso (Osimertinib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Tagrisso (Osimertinib).

Abnormal heart rhythms: Tagrisso (Osimertinib) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Tagrisso (Osimertinib). You are more at risk for this type of abnormal heart rhythm and its complications if you:

are female
are older than 65 years of age
have a family history of sudden cardiac death
have a history of heart disease or abnormal heart rhythms
have a slow heart rate
have congenital prolongation of the QT interval
have Diabetes
have had a Stroke
have low potassium, magnesium, or calcium levels
have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Tagrisso (Osimertinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tagrisso (Osimertinib), and whether any special monitoring is needed.

Birth control: If you or your partner could become pregnant, talk to your doctor about appropriate birth control while using Tagrisso (Osimertinib). Birth control pills may become less effective when taken during treatment with Tagrisso (Osimertinib). Men who are taking Tagrisso (Osimertinib) should not father a child while taking Tagrisso (Osimertinib) and for at least 4 months after completing treatment with Tagrisso (Osimertinib).

Drowsiness/reduced alertness: Tagrisso (Osimertinib) may cause dizziness, vision changes, or other side effects that affect your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how Tagrisso (Osimertinib) affects you.

Eye problems: Tagrisso (Osimertinib) may cause eye inflammation. If you experience blurred vision, dry eyes, eye pain, swelling, redness with a gritty feeling, sensitivity to light, or any other eyesight changes, contact your doctor as soon as possible. Wearing contact lenses increases your risk of eye problems.

Heart problems: Tagrisso (Osimertinib) may cause or worsen symptoms of heart disease. If you have heart disease such as Congestive Heart Failure, or arrhythmia, discuss with your doctor how Tagrisso (Osimertinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tagrisso (Osimertinib), and whether any special monitoring is needed. Contact your doctor as soon as possible if you develop symptoms of heart problems such as shortness of breath, chest pain, rapid heartbeat, or swollen ankles.

Liver function: Tagrisso (Osimertinib) is broken down by the liver. If you have liver problems, discuss with your doctor how Tagrisso (Osimertinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tagrisso (Osimertinib), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Tagrisso (Osimertinib).

Lung inflammation: Lung inflammation (interstitial lung disease), causing difficulty breathing has occurred rarely for some people taking Tagrisso (Osimertinib). This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking Tagrisso (Osimertinib), contact your doctor immediately.

Pregnancy: Tagrisso (Osimertinib) may harm an unborn child if the mother takes it during pregnancy. Tagrisso (Osimertinib) should not be used during pregnancy unless the benefits outweigh the risks. Women who may become pregnant must use an effective birth control method while taking Tagrisso (Osimertinib) and for at least 2 months after taking the last dose of medication. If you become pregnant while taking Tagrisso (Osimertinib), contact your doctor immediately.

Breast-feeding: It is not known if Tagrisso (Osimertinib) passes into breast milk. If you are breast-feeding and are taking Tagrisso (Osimertinib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Tagrisso (Osimertinib) have not been established for children and adolescents younger than 18 years of age.

Seniors: People over the age of 65 may experience side effects from taking Tagrisso (Osimertinib).

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