Dornase alfa is a medication that is used in combination with other medications to treat Cystic Fibrosis. It is used to reduce the risk of respiratory tract infections (e.
Available form
Inhaler
Dosage
Manufacturer
Hoffmann-la Roche
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The usual dose of Pulmozyme (Dornase-alfa) is one 2.5 mg ampule inhaled once a day using the recommended nebulizer. Some people may use Pulmozyme (Dornase-alfa) twice a day if recommended by their doctor.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to use Pulmozyme (Dornase-alfa) exactly as prescribed by your doctor and that you understand how to use and maintain the nebulizer. Read the patient instructions provided and talk to your doctor or pharmacist if you are not sure how to use Pulmozyme (Dornase-alfa) properly. Use the nebulizer and mouthpiece that is recommended or provided to you. Do not mix Pulmozyme (Dornase-alfa) with any other medication in the nebulizer. Before using an ampule, squeeze it to ensure it does not leak. Pulmozyme (Dornase-alfa) contains no preservative and once an ampule is opened, the entire content must be used or discarded.
If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Pulmozyme (Dornase-alfa) in the refrigerator, protect it from light, and keep it out of the reach of children.
Pulmozyme (Dornase-alfa) should be kept refrigerated during travelling and should not be at room temperature for more than 24 hours. If you notice that the solution is cloudy or discoloured, do not use it and discard it.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Pulmozyme (Dornase-alfa). If you are concerned about side effects, discuss the risks and benefits of Pulmozyme (Dornase-alfa) with your doctor.
The following side effects have been reported by at least 1% of people taking Pulmozyme (Dornase-alfa). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pulmozyme (Dornase-alfa).
Each ampule of sterile, clear, colourless, aqueous solution contains dornase alfa 1 mg/mL (2.5 mg). Nonmedicinal ingredients: calcium chloride dihydrate, sodium chloride, and sterile water for injection. Pulmozyme (Dornase-alfa) does not contain any preservatives.
Do not use Pulmozyme (Dornase-alfa) if you:
Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Pulmozyme (Dornase-alfa).
Pregnancy: Pulmozyme (Dornase-alfa) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using Pulmozyme (Dornase-alfa), contact your doctor.
Breast-feeding: It is not known if dornase alfa passes into breast milk. If you are a breast-feeding mother and are using Pulmozyme (Dornase-alfa), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Pulmozyme (Dornase-alfa) have not been established for children less than 5 years old.
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