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Pegasys

Pegasys

(peginterferon-alfa-2a)

Peginterferon alfa-2a belongs to the class of medications known as interferons. It is used to treat chronic hepatitis B and chronic Hepatitis C, which are diseases of the liver.

Available form

Dosage

Injectable

180MCG/ML

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Pegasys information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of peginterferon alfa-2a is 180 µg once weekly for a period of 48 weeks. If there is no improvement after 12 weeks of use, your doctor may stop the treatment. Pegasys (Peginterferon-alfa-2a) is usually injected under the skin (subcutaneously) of the abdomen or thigh.

If you are giving yourself the injections, it is very important that you very carefully follow your health care professional's directions and the instructions included with the medication. After the medication has been mixed, it should be used right away. Needles and syringes should never be reused. All used needles and syringes should be put into a sharps container and kept out of the reach of children.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Pegasys (Peginterferon-alfa-2a) exactly as prescribed by your doctor.

If you miss a dose and remember within 2 days of the scheduled dose, give the dose as soon as possible. If more than 2 days have passed, check with your doctor for further instructions. Do not inject a double dose to make up for a missed one.

Store Pegasys (Peginterferon-alfa-2a) in the refrigerator, protect it from light and moisture, and keep it out of the reach of children. Do not freeze or shake the medication. Do not use Pegasys (Peginterferon-alfa-2a) if it is discoloured or has particles floating in it.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Pegasys (Peginterferon-alfa-2a). If you are concerned about side effects, discuss the risks and benefits of Pegasys (Peginterferon-alfa-2a) with your doctor.

The following side effects have been reported by at least 1% of people taking Pegasys (Peginterferon-alfa-2a). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

back pain
cough
decreased desire for sexual activities
Diarrhea
dry, itchy skin
Dry Mouth
fatigue
flu-like symptoms (unusual tiredness, Fever, chills, muscle aches, joint pain, and Headaches)
hair thinning
loss of appetite
nausea
poor concentration
rash
redness, swelling, bruising, irritation, or itching at the site of the injection
trouble sleeping
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Anemia (paleness, tiredness, shortness of breath)
bloody diarrhea
changes in mood (e.g., irritability, anxiety, aggression)
dizziness
hallucinations (seeing or hearing things that are not there)
high blood sugar (increased thirst, hunger, weakness, drowsiness, blurred vision, weight loss)
loss of coordination
low blood sugar (headache, hunger, weakness, irritability, trouble concentrating)
lower back or side pain
lung problems (e.g., difficulty breathing, pneumonia)
numbness or tingling or burning sensations
persistent cough
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
signs of infection (e.g., chills, fever, cough, sore throat, difficulty or painful urination, difficulty breathing)
ulcers or sores in the mouth or throat
unusual bruising or bleeding (e.g., bleeding gums, nosebleeds, blood in the urine, pinpoint-sized red spots on skin)
vision changes (e.g., blurred vision, loss of vision)
weakness
worsening psoriasis

Stop taking the medication and seek immediate medical attention if any of the following occur:

fast or irregular heartbeat (palpitations)
severe skin rash (blistering, peeling, and spreading)
suicidal feelings or suicide attempts
symptoms of a Heart Attack (e.g., severe chest pain or pressure, pain in the arm or shoulder, nausea, sweating)
symptoms of a Anaphylaxis (severe allergic reaction) (e.g., Hives; difficulty breathing; swelling of the face, mouth, throat, or tongue)
symptoms of a Stroke (e.g., sudden and severe headache, sudden weakness or numbness in the arms or legs, sudden vision changes, sudden dizziness)
trouble breathing

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pegasys (Peginterferon-alfa-2a).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Pegasys (Peginterferon-alfa-2a).

Allergic reactions: In rare cases, Pegasys (Peginterferon-alfa-2a) may cause severe allergic reactions. If you notice hives, swelling of the face or throat, or difficulty breathing, stop using Pegasys (Peginterferon-alfa-2a) and get medical help immediately.

Autoimmune conditions: Pegasys (Peginterferon-alfa-2a) may cause or worsen autoimmune conditions including myositis, hepatitis, immune thrombocytopenic purpura (ITP), Rheumatoid Arthritis, interstitial nephritis, thyroiditis, and systemic Lupus erythematosus. If psoriasis appears, the medication may need to be discontinued.

Blood glucose (sugar): Pegasys (Peginterferon-alfa-2a) can cause low or high blood sugar. People with Diabetes should discuss with their doctor how Pegasys (Peginterferon-alfa-2a) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Pegasys (Peginterferon-alfa-2a), and whether any special monitoring is needed. If you experience high blood sugar (increased thirst, hunger, weakness, drowsiness, blurred vision, weight loss) or low blood sugar (headache, hunger, weakness, irritability, trouble concentrating) while taking Pegasys (Peginterferon-alfa-2a), contact your doctor.

Blood problems: Pegasys (Peginterferon-alfa-2a) may suppress bone marrow function and cause blood problems such as low platelet counts, low white blood cell counts, and anemia. Your doctor will monitor you for these problems with blood tests. If you experience persistent fever and chills, tiredness, shortness of breath, or easy bruising or bleeding, contact your doctor.

Colon disorders: Pegasys (Peginterferon-alfa-2a) may cause certain types of colitis. Report any stomach or abdominal pain, bloody diarrhea, or fever to your doctor immediately.

Depression and other psychiatric conditions: Pegasys (Peginterferon-alfa-2a) can cause depression and other psychiatric conditions. People with psychiatric conditions should be closely monitored by their doctor while using Pegasys (Peginterferon-alfa-2a), as it may worsen these conditions.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Pegasys (Peginterferon-alfa-2a), contact your doctor as soon as possible.

Dizziness/reduced alertness: Peginterferon alfa-2a may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Pegasys (Peginterferon-alfa-2a) affects you.

Eye disorders: Certain eye disorders have been observed in people using Pegasys (Peginterferon-alfa-2a). If you experience any changes in vision while taking Pegasys (Peginterferon-alfa-2a), contact your doctor.

Flu-like symptoms: Pegasys (Peginterferon-alfa-2a) may cause a flu-like reaction with aching muscles, fever, chills, and headache. Your doctor may prescribe Acetaminophen before each dose of Pegasys (Peginterferon-alfa-2a) and as needed to help reduce these symptoms.

Fluids: Pegasys (Peginterferon-alfa-2a) may cause dehydration. People taking Pegasys (Peginterferon-alfa-2a) should drink adequate fluids, especially on hot days or when exercising.

Heart disease: Pegasys (Peginterferon-alfa-2a), as well as others like it, can cause heart problems such as high blood pressure, chest pain, heart attack, abnormal heart rhythms, and heart failure. If you have had a heart attack, heart failure, or changes in heart rhythm (Arrhythmias), discuss with your doctor how Pegasys (Peginterferon-alfa-2a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pegasys (Peginterferon-alfa-2a), and whether any special monitoring is needed. People with severe, unstable, or uncontrolled heart disease should not use Pegasys (Peginterferon-alfa-2a).

Kidney Disease: People with kidney disease should discuss with their doctor how Pegasys (Peginterferon-alfa-2a) may affect their medical condition and whether any special monitoring is needed. People with reduced kidney function may require a lower dose.

Liver function: People who are taking Pegasys (Peginterferon-alfa-2a) will need frequent checkups to test their liver function. People with reduced liver function may require a lower dose of the medication or may need to stop taking it.

Lung disorders: Certain lung disorders may occur in people using Pegasys (Peginterferon-alfa-2a), causing breathing difficulty. These conditions can be fatal. If you experience fever, cough, or shortness of breath, contact your doctor as soon as possible.

Pancreatitis: Pegasys (Peginterferon-alfa-2a) may cause pancreatitis, which may be fatal. If you develop symptoms of pancreatitis (e.g., severe abdominal pain with or without vomiting), get immediate medical attention.

Stroke: Pegasys (Peginterferon-alfa-2a) has been associated with strokes. If you experience symptoms of a stroke (e.g., sudden and severe headache, sudden weakness or numbness in the arms or legs, sudden vision changes, sudden dizziness) while taking Pegasys (Peginterferon-alfa-2a), get immediate medical attention.

Thyroid disorders: Pegasys (Peginterferon-alfa-2a) can cause or worsen Hypothyroidism (low thyroid) or Hyperthyroidism (high thyroid). People with thyroid conditions should discuss with their doctor how Pegasys (Peginterferon-alfa-2a) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Pegasys (Peginterferon-alfa-2a), and whether any special monitoring is needed.

Transplants: The safety and effectiveness of using Pegasys (Peginterferon-alfa-2a) have not been established for people who have had a liver or other organ transplant.

Pregnancy: Pegasys (Peginterferon-alfa-2a) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Pegasys (Peginterferon-alfa-2a), contact your doctor immediately. Women who may become pregnant should use an effective method of birth control while using peginterferon alfa-2a.

Breast-feeding: It is not known if peginterferon alfa-2a passes into breast milk. If you are a breast-feeding mother and are taking Pegasys (Peginterferon-alfa-2a), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of using Pegasys (Peginterferon-alfa-2a) have not been established for children under the age of 18. Pegasys (Peginterferon-alfa-2a) is not recommended for use by newborns or infants because peginterferon alfa-2a contains benzyl alcohol and may be harmful.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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