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Grastofil

Grastofil

(filgrastim)

Grastofil (Filgrastim) belongs to the family of medications known as granulocyte colony stimulating factors (G-CSF). It helps the bone marrow produce white blood cells, which help the body fight infection.

Available form

Dosage

Injectable Syringe

300MCG/0.5ML, 480MCG/0.8ML

Buy Grastofil Full drug details

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Grastofil information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended starting dose of Grastofil (Filgrastim) is based on body weight and varies depending on the condition being treated. For people who are being treated with chemotherapy, treatment should start no sooner than 24 hours after the chemotherapy has been given.

Grastofil (Filgrastim) is given by subcutaneous (under the skin) or intravenous (into a vein) injection once daily. Your dose may be adjusted depending on your response to Grastofil (Filgrastim), and therapy is usually continued until neutrophil counts reach an acceptable level. For some conditions, Grastofil (Filgrastim) will be needed indefinitely.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Grastofil (Filgrastim) is usually given under medical supervision. If you are giving Grastofil (Filgrastim) to yourself, your doctor or health care professional will instruct you on how to use Grastofil (Filgrastim) properly. It is important that Grastofil (Filgrastim) be used exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

If you are receiving Grastofil (Filgrastim) in a clinic or at your doctor’s office and you miss an appointment to receive Grastofil (Filgrastim), contact your doctor as soon as possible to reschedule your appointment.

Store Grastofil (Filgrastim) in the refrigerator, but do not allow it to freeze. Avoid shaking Grastofil (Filgrastim). Store it in the carton it is packaged in to protect it from light. Grastofil (Filgrastim) may be stored out of the refrigerator, at room temperature, for a single period of up to 7 days. Keep Grastofil (Filgrastim) out of the reach of children. Do not use Grastofil (Filgrastim) if it is cloudy or there are particles in it.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Grastofil (Filgrastim). If you are concerned about side effects, discuss the risks and benefits of Grastofil (Filgrastim) with your doctor.

The following side effects have been reported by at least 1% of people taking Grastofil (Filgrastim). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

cough
Diarrhea
fatigue
headache
joint swelling and pain
loss of appetite
a lump, redness, swelling, or bruising at the injection site
muscle pain
sore throat

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

acute respiratory distress syndrome (e.g., fever, shortness of breath, cough, lung congestion)
bone pain
enlarged spleen (increased tenderness or swelling in the left upper stomach area)
inflammation of the blood vessels in the skin
raised, painful, plum-coloured sores on the limbs, face or neck
signs of bleeding (such as nosebleeds, blood in the urine, black tarry stools, bleeding gums, coughing or throwing up of blood, easy bruising)

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
symptoms of capillary leak syndrome (e.g., swelling or puffiness, decreased urine production or need to pass water, difficulty breathing, abdominal swelling, general feeling of tiredness)
symptoms of a ruptured spleen (e.g., pain in the left upper stomach area or left shoulder tip area)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Grastofil (Filgrastim).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Grastofil (Filgrastim).

Capillary leak syndrome (CLS): Grastofil (Filgrastim) has been reported to cause CLS, a condition where blood leaks out of the small blood vessels into the tissues of the body. If you experience symptoms of CLS, such as swelling or puffiness, decreased need to urinate, trouble breathing, swelling in the abdominal area, or a general feeling of tiredness, contact your doctor immediately. The symptoms often develop quickly and the severity of each episode is different. In severe episodes, CLS can be fatal.

Chronic use: When used for long periods of time, Grastofil (Filgrastim) may increase the risk of myelodysplasia (bone marrow disorders) and certain types of leukemia. It is not known if this increased risk is directly related to Grastofil (Filgrastim) or to the conditions Grastofil (Filgrastim) is being used to treat. If you are receiving long-term treatment with Grastofil (Filgrastim), your doctor will monitor your blood regularly and check your bone marrow annually.

Cytotoxic chemotherapy: The safety of using Grastofil (Filgrastim) at the same time as cytotoxic chemotherapy (a type of chemotherapy that kills cells, especially cancer cells) has not been established. Grastofil (Filgrastim) should not be used within 24 hours before or 24 hours after chemotherapy is administered.

Heart conditions: Heart-related conditions such as heart attacks and abnormal heart rhythms have been observed in rare cases with Grastofil (Filgrastim). If you have a heart condition before starting Grastofil (Filgrastim), discuss with your doctor how Grastofil (Filgrastim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Grastofil (Filgrastim), and whether any special monitoring is needed.

Lung problems: Grastofil (Filgrastim) may cause acute respiratory distress syndrome (ARDS), a serious lung condition. It is thought that this is caused by the movement of white blood cells to an area of the lung that is inflamed, as a result of infection. If you experience difficulty breathing, fever, or coughing blood while using Grastofil (Filgrastim), contact your doctor immediately.

Osteoporosis: Long-term use of Grastofil (Filgrastim) may increase the risk of osteoporosis in some people. If you have osteoporosis or chronic neutropenia, discuss with your doctor how Grastofil (Filgrastim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Grastofil (Filgrastim), and whether any special monitoring is needed. Your doctor may want to check your bone density regularly while you are receiving Grastofil (Filgrastim).

Sickle cell disease: Grastofil (Filgrastim) may cause sickle cell crisis when used by people who have sickle cell disease. You and your doctor should carefully consider the benefits and risks of using Grastofil (Filgrastim) in these circumstances if you have sickle cell disease.

Splenic rupture: Using Grastofil (Filgrastim) can cause the spleen to enlarge and in some cases rupture, causing internal bleeding. A ruptured spleen is a medical emergency. Symptoms of a ruptured spleen include pain on the left side of the abdomen, under the rib cage, or pain at the tip of your left shoulder. Other symptoms include symptoms of shock, including lightheadedness or fainting, blurred vision, confusion, anxiety, nausea, or paleness. If you experience any of these, seek immediate medical help.

Pregnancy: Grastofil (Filgrastim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Grastofil (Filgrastim), contact your doctor immediately.

Breast-feeding: It is not known whether Grastofil (Filgrastim) passes into breast milk. If you are a breast-feeding mother and are taking Grastofil (Filgrastim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Grastofil (Filgrastim) have not been established for newborn babies.

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