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Esbriet

Esbriet

(pirfenidone)

Esbriet (Pirfenidone) belongs to the class of medications known as antifibrotics. It is also an anti-inflammatory.

Available form

Dosage

Capsule

267MG

Buy Esbriet Full drug details

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Esbriet information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

For the first 7 days of treatment, the dose of Esbriet (Pirfenidone) is 267 mg taken 3 times a day. For the next 7 days (day 8 to day 14), increase the dose to 534 mg taken 3 times a day. From day 15 onwards, increase the dose to 801 mg taken 3 times per day. Esbriet (Pirfenidone) should be taken with food, or during or after a meal to reduce side effects such as stomach problems and dizziness. Swallow each capsule whole with water. Your doctor may adjust your dose depending on how you tolerate Esbriet (Pirfenidone).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Esbriet (Pirfenidone) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with the next dose in your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. If you miss taking Esbriet (Pirfenidone) for 14 days in a row or more, contact your doctor, as you will need to restart treatment with increasing doses.

Store Esbriet (Pirfenidone) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Esbriet (Pirfenidone). If you are concerned about side effects, discuss the risks and benefits of Esbriet (Pirfenidone) with your doctor.

The following side effects have been reported by at least 1% of people taking Esbriet (Pirfenidone). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
bloating
Constipation
decreased appetite
Diarrhea
difficulty sleeping
headache
indigestion, heartburn, or acid reflux
itchy, dry, or red skin
muscle or joint aches or pains
nausea
rash
sun sensitivity (e.g., Sunburn, skin rash, blistering or peeling skin)
tiredness or weakness
vomiting
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

dizziness
fast, slow, or irregular heart beat
symptoms of infection (Fever, cough, sinus congestion or pain, difficult or painful urination)
symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools, itching)

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
signs of a serious allergic reaction (e.g., Hives; difficulty breathing or swallowing; or swelling of the face, lips, tongue, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Esbriet (Pirfenidone).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Esbriet (Pirfenidone).

HEALTH CANADA ADVISORY

September 14, 2020

Health Canada has issued new information concerning the use of Esbriet (Pirfenidone). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Fatigue and dizziness: Esbriet (Pirfenidone) can cause fatigue and dizziness. Do not drive or operate machinery until you know that Esbriet (Pirfenidone) does not affect your ability to perform these activities safely. To reduce dizziness, take Esbriet (Pirfenidone) with food.

Kidney function: If you have Kidney Disease, discuss with your doctor how Esbriet (Pirfenidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Esbriet (Pirfenidone), and whether any special monitoring is needed. If you have severely reduced kidney function or are receiving dialysis treatment, you should not take Esbriet (Pirfenidone).

Liver function: Liver disease or reduced liver function may cause Esbriet (Pirfenidone) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Esbriet (Pirfenidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Esbriet (Pirfenidone), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Esbriet (Pirfenidone).

If you experience symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools, itching) while taking Esbriet (Pirfenidone), contact your doctor.

If you have severe liver disease, you should not take Esbriet (Pirfenidone).

Sun sensitivity: Esbriet (Pirfenidone) may increase the sensitivity of your skin to the sun. Avoid exposure to direct and indirect sunlight (including sunlamps and window light), use an effective sunblock daily (at least SPF 50 for UVA and UVB), and wear clothing that protects you from the sun (e.g., hat, long-sleeves) while taking Esbriet (Pirfenidone). If you get a skin reaction (e.g., rash, sunburn, blistering, peeling) from the sun, contact your doctor.

Weight loss: Esbriet (Pirfenidone) may cause loss of appetite and weight loss. Your doctor will monitor your weight while you are taking Esbriet (Pirfenidone).

Pregnancy: Esbriet (Pirfenidone) should not be used during pregnancy. If you become pregnant while taking Esbriet (Pirfenidone), contact your doctor immediately.

Breast-feeding: It is not known if Esbriet (Pirfenidone) passes into breast milk. If you are a breast-feeding mother and are taking Esbriet (Pirfenidone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Esbriet (Pirfenidone) have not been established for anyone under the age of 18.

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