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Act Repaglinide

Act Repaglinide

(repaglinide)

Repaglinide belongs to the class of medications called antidiabetes agents. It is an oral hypoglycemic (lowering of blood sugar) medication used by people with Type 2 Diabetes, along with proper diet and exercise, for the control of blood sugar.

Available form

Dosage

Tablet

0.5MG, 1MG, 2MG

Buy Act Repaglinide Full drug details

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Act Repaglinide information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of repaglinide is based on response to the medication, but is usually started at 0.5 mg. It can be taken either immediately before a meal or up to 30 minutes before a meal. The dose is increased by your doctor based on your response to the medication. The maximum daily dose is 16 mg. Repaglinide may be used along with other medications that reduce blood sugar if one medication is not enough to reduce blood sugar levels to the desired range.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Act Repaglinide exactly as prescribed by your doctor. If you miss a dose of Act Repaglinide, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Act Repaglinide at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Act Repaglinide. If you are concerned about side effects, discuss the risks and benefits of Act Repaglinide with your doctor.

The following side effects have been reported by at least 1% of people taking Act Repaglinide. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
back pain
Constipation
Diarrhea
dizziness
fatigue
headache
joint pain
nausea
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

bloody or cloudy urine
burning, painful, or difficult urination
chills
cough
Fever
low blood sugar, including:

anxious feeling
behavioural change similar to being drunk
blurred vision
cold sweats
confusion
cool pale skin
difficulty thinking
drowsiness
excessive hunger
fast heartbeat
headache
nausea
nervousness
nightmares
restless sleep
shakiness
slurred speech
unusual tiredness or weakness

runny or stuffy nose
shortness of breath
signs of liver damage:

abdominal pain
dark urine
fatigue
fever
loss of appetite
yellow skin or eyes

sinus congestion with pain
sneezing
sore throat
vision changes
wheezing

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
convulsions (seizures)
fast or irregular heartbeat
signs of an allergic reaction, e.g.:

difficulty breathing
Hives
swelling of the face or throat

signs of bleeding, e.g.:

bleeding gums
blood in the urine
dark tarry stools
easy bruising
nosebleeds
vomiting blood

unconsciousness

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Act Repaglinide.

There may be an interaction between repaglinide and any of the following:

Abiraterone
ACE inhibitors (e.g., Ramipril, Lisinopril)
anti-psychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, olanzepine, Quetiapine, Risperidone)
barbiturates (e.g., Phenobarbital)
beta-blockers (e.g., Propranolol, Metoprolol)
birth control pills
boceprevir
Bosentan
calcium channel blockers (e.g., Nifedipine, Verapamil)
Carbamazepine
Celecoxib
clopidogrel
corticosteroids (e.g., Dexamethasone, Prednisone)
Cyclosporine
Dabrafenib
Danazol
Deferasirox
other diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, metformin, Nateglinide, rosiglitazone, Sitagliptin)
diuretics (e.g., Furosemide, Hydrochlorothiazide)
Eltrombopag
Enzalutamide
estrogens
gemfibrozil
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., darunavir, indinavir, lopinavir, saquinavir, tipranavir)
Irbesartan
isoniazid

itraconazole
ketoconazole
Losartan
macrolide antibiotics (e.g., clarithromycin, erythromycin)
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
nefazodone
nicotinic acid
nonsteroidal anti-inflammatory drugs (e.g., Ibuprofen, Naproxen)
Octreotide
Phenytoin
primidone
Progesterone
quinine
quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
rifabutin
rifampin
rifapentine
ritonavir
St. John's wort
salicylates (e.g., Asa)
selective serotonin reuptake inhibitors (SSRI; e.g., Fluoxetine, Paroxetine, Sertraline)
Stiripentol
sulfonamides (e.g., sulfamethoxazole)
Tacrolimus
Tamoxifen
testosterone
Trimethoprim

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than the ones listed above may interact with Act Repaglinide. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Act Repaglinide.

HEALTH CANADA ADVISORY

July 31, 2015

Health Canada has issued new restrictions concerning the use of gluconorm (repaglinide). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Blood sugar control: If you are exposed to extra stress such as fever, trauma, infection, or surgery, your blood sugar control may vary. Monitor your blood sugar carefully and call the doctor if any important changes occur in your control.

Hypoglycemia (low blood sugar): Hypoglycemia (low blood sugar) can occur when taking repaglinide. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking Act Repaglinide, contact your doctor.

Kidney function: If you have decreased kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Act Repaglinide, and whether any special monitoring is needed.

Liver function: Reduced liver function may cause higher levels of repaglinide in the body and increase the risk for low blood sugar levels (hypoglycemia). Make sure you report all your medical conditions to your doctor(s). People with severe liver disease should not take repaglinide.

Missed or delayed meals: This medication acts by promoting the secretion of insulin and should be taken before meals. If a meal is skipped or delayed, the dosing of repaglinide should be skipped or delayed as well.

Pregnancy: Act Repaglinide should not be used during pregnancy. If you become pregnant while taking Act Repaglinide, contact your doctor immediately.

Breast-feeding: It is not known whether repaglinide passes into breast milk. If you are a breast-feeding mother and are taking Act Repaglinide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: This safety and effectiveness of using this medication have not been established for children.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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